Is Adderall Overdose Life-Threatening?
Medically Reviewed By
Written By
Last medically reviewed : March 17, 2025
Updated On : March 17, 2025
Medically Reviewed By
Written By
Last medically reviewed : March 17, 2025
Updated On : March 17, 2025
Adderall is a prescription medication classified as an amphetamine, primarily used to treat attention-deficit hyperactivity disorder (ADHD).[1] It works by stimulating activity in the central nervous system, which helps users focus and pay attention.[2] While Adderall is beneficial for millions of people, it also has the potential for abuse and misuse.[3] This abuse can put users at risk of experiencing an overdose.
In this blog, you will learn about the causes of an Adderall overdose, the symptoms associated with an overdose, and whether it can be fatal.
Yes, if you misuse Adderall by taking more than prescribed, it is possible to overdose.[4]
Adderall misuse can occur if you:[5]
An Adderall overdose, also called Adderall toxicity, can cause you to become incoherent and unable to communicate. Therefore, if you’ve taken more Adderall than prescribed, or you suspect someone you love has taken a toxic amount, contact poison control right away. If they are unresponsive, call emergency services immediately.
Taking more than the prescribed amount of Adderall can be dangerous and even life-threatening. It’s important to note that the risk of overdose varies based on individual factors such as age, weight, and metabolism. While the exact dosage that leads to an overdose differs from person to person, studies indicate that exceeding 40 mg in a day significantly increases these risks.[6]
In fact, research published in the Topics in Companion Animal Medicine suggests that as little as 1.5 mg/kg can be lethal in humans.[7] Therefore, to avoid an overdose, users should stay within the recommended dosage.
The symptoms of an Adderall overdose will occur soon after taking the toxic dose or mixing it with a contraindicated drug.
These symptoms range in severity and include:[8]
A person who overdoses on Adderall multiple times may be struggling with an addiction. If you or someone you know uses more Adderall than prescribed or uses it despite no longer needing it, you may need help quitting.
Contact Engage Wellness Acton to learn about our treatment options for Adderall addiction. We can help you get your life back on track.
Individuals who use Adderall long-term or abuse high doses (substance abuse) can develop tolerance to its effects. According to the Merck Manuals, people who have a tolerance to Adderall will need an even higher dose to feel the original effects.[9] These users may, unfortunately, develop troubling side effects such as confusion, anxiety, psychosis, and paranoia.
Experiencing these effects may cause the person to abruptly stop taking Adderall, leading to amphetamine withdrawal. This condition can last anywhere from five days to four weeks and includes symptoms such as insomnia, suicidal thoughts, depression, and restlessness.[10] Unfortunately, during this period, they may re-initiate use to stave off withdrawal, unintentionally ingesting a toxic amount.
An Adderall overdose is dangerous and requires prompt emergency care. Although many prescription stimulants have antidotes to reverse their toxic effects, Adderall isn’t one of them. Treatment consists of supportive measures and life-saving techniques to treat the symptoms of the overdose.
A standard Adderall overdose treatment protocol includes:[11]
After treating an overdose, additional care is often needed to reduce the risk of future occurrences. This includes cognitive behavioral therapy and attending peer support groups.[12]
The effects of Adderall overdose are classed as short-term and long-term. Most people experiencing an overdose will have short-term effects that make it impossible to function without medical care. Long-term effects stem from the complications of these short-term effects.
Common short-term effects include:[9]
Long-term effects usually impact the individual’s mental health and can include:[9]
An overdose can indicate a substance use disorder (SUD), which often arises from the abuse of prescription or street drugs.[13] If left untreated, this condition can lead to addiction. To address Adderall addiction, dual-diagnosis treatment programs are effective as they tackle both the substance use disorder and any underlying mental health conditions that may contribute to it. These programs also incorporate medication-assisted treatment, helping individuals safely and comfortably wean off Adderall while minimizing the risk of future overdoses.
Not only is taking too much Adderall life-threatening, but it increases the risk of Adderall abuse. People who abuse Adderall can behave erratically, endangering their lives and the lives of those around them. They may also struggle to stop the use of Adderall despite no longer wanting to take it.
Additional signs of Adderall abuse include:[14]
Taking Adderall as prescribed is the best way to avoid suffering an overdose. However, there are other actions you can take to reduce the risk of taking a toxic amount.
They include:
You may have an Adderall Addiction if you are using Adderall despite no longer wanting to and experiencing cravings when you stop.
However, the criteria for a substance use disorder is someone who exhibits at least two of the following symptoms over the last 12 months:[15]
If you have experienced two or more of these signs, you may have an addiction to Adderall. Rehab can help you understand why you developed this addiction and assist you in treating it.
Some individuals avoid rehabilitation because they prefer not to stay at the facility. The good news is that substance use disorder (SUD) treatment programs are available in various formats, not just on an inpatient basis. Some people participate in day treatment, attending rehab for a few hours each day before returning home, while others may stay in nearby accommodations to receive care.
To learn more about treatment programs for Adderall addiction and the various levels of care available, contact Engage Wellness Acton today.
Yes. An overdose of Adderall can cause life-threatening effects, including seizures and coma.
Yes. Adderall is a Schedule II Controlled substance with a high potential for misuse and abuse.
Yes. Abruptly stopping Adderall after long-term use can trigger withdrawal symptoms as the brain struggles to regulate dopamine.
[1] Cancer.gov. (n.d.) Adderall Definition. Retrieved from https://www.cancer.gov/publications/dictionaries/cancer-terms/def/adderall on 2025 Feb 12.
[2] MedlinePlus. (2024 Jul 20) Dextroamphetamine and Amphetamine. Retrieved from https://medlineplus.gov/druginfo/meds/a601234.html on 2025 Feb 12.
[3] USA Facts. (2023 Apr 26) Who is Impacted by the Nationwide Adderall Shortage? Retrieved from https://usafacts.org/articles/when-will-the-adderall-shortage-end/ on 2025 Feb 12.
[4] AccessData FDA. (2023 Oct) Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/011522s045lbl.pdf on 2025 Feb 12.
[5] MedlinePus. (n.d.) Prescription Drug Misuse. Retrieved from https://medlineplus.gov/prescriptiondrugmisuse.html on 2025 Feb 12.
[6] Drugs.com. (2024 Jul 22) How Much Adderall Can I Take? Retrieved from https://www.drugs.com/medical-answers/how-much-adderall-take-3560126/ on 2025 Feb 12.
[7] Science Direct. (2013 Feb) Adderall ( Amphetamine-Dextroamphetamine) Toxicity. Retrieved from https://www.sciencedirect.com/science/article/abs/pii/S193897361300024X on 2025 Feb 12.
[8] Better Health. (2023 May 19) Amphetamines. Retrieved from https://www.betterhealth.vic.gov.au/health/healthyliving/amphetamines on 2025 Feb 12.
[9] Merck Manuals. (2022 Dec) Retrieved from https://www.merckmanuals.com/home/special-subjects/illicit-drugs-and-intoxicants/amphetamines on 2025 Feb 12.
[10] Drugs.com. (2024 Apr 9) How Long Does Adderall Withdrawal Last? Retrieved from https://www.drugs.com/medical-answers/long-adderall-withdrawal-3572393/ on 2025 Feb 12.
[11] National Library of Medicine. (2024 May 6) Amphetamine Toxicity. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK470276/ on 2025 Feb 12.
[12] National Library of Medicine. (2011 Sep 1) Cognitive-Behavioral Therapy for Substance Use Disorder. Retrieved from https://pmc.ncbi.nlm.nih.gov/articles/PMC2897895/ on 2025 Feb 12.
[13] American Psychiatric Association. (2024 Apr) What is Substance Use Disorder? Retrieved from https://www.psychiatry.org/patients-families/addiction-substance-use-disorders/what-is-a-substance-use-disorder on 2025 Feb 12.
[14] Mayo Clinic (2022 Oct 4) Drug Addiction (Substance Use Disorder). Retrieved from https://www.mayoclinic.org/diseases-conditions/drug-addiction/symptoms-causes/syc-20365112 on 2025 Feb 12.
[15] National Library of Medicine. (2014 Aug 1) DSM-5 Criteria for Substance Use Disorders: Recommendations and Rationale. Retrieved from https://pmc.ncbi.nlm.nih.gov/articles/PMC3767415/ on 2025 Feb 12.